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From209US$ /night
Check-in
08Jan2026Select date
Check-out
09Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

Hotel Overview

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Steps from the Ohio River
Great
8.7
9.3
/10
4.7
4.6
/5

21C Museum Hotel Louisville - Boutique hotel with contemporary art exhibits near Muhammad Ali Center

Located in downtown Louisville, this hotel combines a contemporary art museum with a 91-room boutique hotel. Guests have access to over 9,000 square feet of exhibition space featuring curated global artworks. The property is within a half mile of the Kentucky Museum of Art & Craft, Frazier International History Museum, and Muhammad Ali Center. Dining options include Proof on Main, serving southern and Appalachian-inspired cuisine with a bourbon bar. The free electric ZeroBus stops two roads away, providing access to downtown attractions like Whiskey Row and Slugger Field. The hotel offers a 24-hour fitness center, sauna, steam room, and pet-friendly rooms.

Additional perks of the hotel

Free access to rotating contemporary art exhibitions

Onsite Reflexology treatments focusing on reflex points in feet, hands, and ears

Event spaces for 10-60 guests with tailored catering by Proof on Main

River City Tintype offers historic photography experiences

Eco-conscious meeting planning available

Private bourbon barrel program at Proof on Main lounge

Rooms & Suites

Guest rooms feature original artwork and premium Bryte Restorative Sleep Beds with adjustable temperature and firmness. The Atrium Suite includes a king bed, living/dining area, tub, and walk-in shower. Corner Suites offer four windows with views of 7th Street, Main Street, and the Ohio River. The Asleep in the Cyclone suite is an artist-designed installation with a king platform bed, record player, and curated components. All accommodations include 50-55" HDTVs, Lavazza coffee, and Malin+Goetz bath amenities.

Other conveniences

Ironing facilities and trouser press in rooms

Mini-bar and tea/coffee maker

Soundproofed rooms with carpeted floors

Private bathrooms with free toiletries and bathrobes

Some rooms feature city views

Laundry service available

Must-do experiences

  • Savor a Hot Brown at the Brown Hotel for a true Louisville classic.
  • Visit the Louisville Waterfront Park for stunning river views and trails.
  • Explore the Speed Art Museum for an impressive art collection.
  • Join a local bourbon tour to taste spirits at iconic distilleries.
  • Check out the NuLu district for unique shops and vibrant street art.
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Choose Your Room

Our listed hotels offer a variety of room types—double rooms, family suites, or deluxe options—all with features like breakfast, flexible cancellation policies, and exclusive deals.
Room Balcony
2 persons
29 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
31 m² 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
61 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
46 m² 
1 King-size bed
Shower
Coffee machine
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Room Rates & Availability Tracker

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Amenities

Thoughtful hotel amenities for a comfortable stay

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
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Dining Onsite

Engage the palate with the distinctive flavors of American cuisine at Proof on Main, where modern decor meets a vibrant dining experience. Seasonal events like the Fork & Bottle dinner series and the annual Hog & Barrel feast showcase regional spirits and exceptional local fare, making each visit a memorable culinary exploration.
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo

Proof on Main

American
Ambiance
Modern
Key Offerings
Highlighting seasonal ingredients, Proof on Main features unique events such as the Fork & Bottle dinner series, where guest distillers present their craft alongside expertly paired dishes. The annual Hog & Barrel dinner celebrates Pappy Van Winkle, creating a unique showcase of local flavors and spirits.
Reservation
Recommended due to special events and dining experiences.
Hours vary.

Hotel Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
180 m
Museum
Muhammad Ali Center
280 m
Museum
Kentucky Science Center
140 m
Museum
The Frazier History Museum
260 m
Museum
Kentucky Museum of Art and Craft
70 m
528 W Main St
Evan Williams Bourbon Experience
200 m
Gallery
Flame Run Glass Studio and Gallery
300 m
500 W Main St
The Belvedere
250 m
Night club
Jimmy Can't Dance
90 m
801 W Main St
Michter's Fort Nelson Distillery
150 m
Library
Sons of the American Revolution Genealogical Research Library
190 m
120 N 10th St
Kentucky Peerless Distilling Co
480 m
401 W River Rd
Belle of Louisville Riverboats
580 m
Restaurants
Proof On Main
10 m
702 West Main Street
Mussel & Burger Bar Downtown
60 m
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
110 m
614 W Main St
Atlantic No. 5
160 m
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
180 m
445 E Market St
Vincenzo's Italian Restaurant
430 m
150 S 5th St
Jockey Silks Bourbon Bar
480 m
140 N 4th St 2nd Floor - West Tower
Dish on Market
470 m
434 W Market St
Quiznos
540 m
223 S 5th St
Swizzle Dinner & Drinks
530 m
140 N Fourth St 25th Floor
Cafe Magnolia
590 m
140 N 4th St Galt House Hotel
Explore Louisville
Explore Louisville
Top Attractions
Activities
Dining
Entertainment
Kentucky Science Center
Kentucky Science Center
2 minutes walking
Hands-on exhibits and an IMAX theatre for all ages make this a must-visit for families and curious minds.
Louisville Slugger Museum & Bat Factory
Louisville Slugger Museum & Bat Factory
3 minutes walking
This iconic museum showcases the history of baseball bats and offers factory tours. Perfect for sports enthusiasts.
Muhammad Ali Center
Muhammad Ali Center
4 minutes walking
A multi-faceted center dedicated to the life and legacy of Muhammad Ali, featuring inspiring exhibits and photos.
Waterfront Park
Waterfront Park
17 minutes walking
Beautiful waterfront views, walking paths, and greenery, ideal for a leisurely stroll or family picnics.
Thrill-seeking Kayaking
5 minutes driving
Rent kayaks and paddle along the Ohio River for a thrilling outdoor adventure. Rental options nearby.
Yoga Classes at Waterfront Park
17 minutes walking
Relax with outdoor yoga sessions at Waterfront Park. Check local listings for schedules and class details.
Jim Beam Urban Stillhouse Tour
11 minutes walking
Tour the distillery, learn about bourbon-making, and enjoy tastings. Reservations recommended.
Proof On Main
Proof On Main
1 minute walking
Contemporary Southern cuisine with a focus on local ingredients and an extensive bourbon selection.
Mussel & Burger Bar Downtown
Mussel & Burger Bar Downtown
1 minute walking
Casual eatery known for signature burgers and fresh mussels. A great spot for families or a quick bite.
Bristol Bar & Grille
Bristol Bar & Grille
2 minutes walking
Casual dining experience featuring diverse menu options, including sustainable and local dishes.
Los Aztecas Mexican Restaurant
Los Aztecas Mexican Restaurant
3 minutes walking
Authentic Mexican flavors in a vibrant atmosphere. Vegan options available; reservations not required.
KFC Yum Center
KFC Yum Center
9 minutes walking
Home of concerts and sports events, offering a lively atmosphere and an exciting lineup year-round.
Fourth Street Live
Fourth Street Live
10 minutes walking
A bustling entertainment venue with live music, bars, and restaurants; perfect for a night out.
The Frazier History Museum
The Frazier History Museum
4 minutes walking
Rich in history, featuring exhibits on Kentucky's heritage. Family-friendly with interactive displays.
Transportation Tips
City Centre
Louisville23 min  ·  1.9 km
Airports
Louisville International Airport (SDF)18 min  ·  11.9 km
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
is available in for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel
Questions of the users
About 21C Museum Hotel Louisville
Are there balcony options available in the guest rooms?
12 December 2024
Luxury King rooms do not feature balconies, but there are two balcony suites and a penthouse with a spacious 2000 sq. ft. terrace available for booking.
What parking facilities are available for guests?
5 February 2025
Valet parking is provided at a rate of $32 per night, offering unlimited access to your vehicle. Additional self-parking options are available on the surrounding streets and in a nearby parking garage.
What is the pet policy for small dogs?
3 March 2025
A pet fee of $75 per room applies for small dogs weighing under 20 lbs. Feel free to ask for more details or specific arrangements.
Is there a special arrangement for wedding guests regarding room bookings?
18 January 2025
Room blocks and special rates can be arranged for wedding parties. Contacting the sales team directly would provide tailored options.
Do the balcony rooms offer a view of the river?
24 November 2024
Balcony rooms face 7th Street, while Corner Suites, which do not have balconies, offer excellent views of the river.
Can I expect a bathtub in the standard double rooms?
27 April 2025
All Deluxe Double Rooms come equipped with bathtubs to enhance guest comfort during their stay.
Are soaking tubs available in any of the guest rooms?
22 March 2025
Soaking tubs are not available in the individual guest rooms, but standard bathtubs are included in some accommodations.
Is there a honeymoon suite or special packages for newlyweds?
14 February 2025
Honeymoon suites can be created from any of the suites through the Love Birds Package, which includes a $100 dinner credit, sparkling wine, and chocolate-covered strawberries upon arrival.
What dining options are available for breakfast at the hotel?
9 October 2024
Breakfast is served through sit-down service with individually priced options. Guests who book a breakfast package receive $18 per person each day towards their meal.
Are rollaway beds available for additional guests?
17 September 2024
Rollaway beds can be requested but are limited in supply. It's best to call the hotel to arrange this in advance during the booking process.
Do rooms come with refrigerators for personal items?
30 August 2024
While rooms include stocked minibars, empty refrigerators are not provided. Guests can request a mini-fridge upon booking by contacting the hotel directly.

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