21C MUSEUM HOTEL LOUISVILLE | Stay downtown in Louisville

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Hotel Overview

700 W Main Street, Louisville, Kentucky, United States, 40202

21C Museum Hotel Louisville - Boutique hotel with contemporary art exhibits near Muhammad Ali Center

Located in downtown Louisville, this hotel combines a contemporary art museum with a 91-room boutique hotel. Guests have access to over 9,000 square feet of exhibition space featuring curated global artworks. The property is within a half mile of the Kentucky Museum of Art & Craft, Frazier International History Museum, and Muhammad Ali Center. Dining options include Proof on Main, serving southern and Appalachian-inspired cuisine with a bourbon bar. The free electric ZeroBus stops two roads away, providing access to downtown attractions like Whiskey Row and Slugger Field. The hotel offers a 24-hour fitness center, sauna, steam room, and pet-friendly rooms.

Additional perks of the hotel

Free access to rotating contemporary art exhibitions

Onsite Reflexology treatments focusing on reflex points in feet, hands, and ears

Event spaces for 10-60 guests with tailored catering by Proof on Main

River City Tintype offers historic photography experiences

Eco-conscious meeting planning available

Private bourbon barrel program at Proof on Main lounge

Rooms & Suites

Guest rooms feature original artwork and premium Bryte Restorative Sleep Beds with adjustable temperature and firmness. The Atrium Suite includes a king bed, living/dining area, tub, and walk-in shower. Corner Suites offer four windows with views of 7th Street, Main Street, and the Ohio River. The Asleep in the Cyclone suite is an artist-designed installation with a king platform bed, record player, and curated components. All accommodations include 50-55" HDTVs, Lavazza coffee, and Malin+Goetz bath amenities.

Other conveniences

Ironing facilities and trouser press in rooms

Mini-bar and tea/coffee maker

Soundproofed rooms with carpeted floors

Private bathrooms with free toiletries and bathrobes

Some rooms feature city views

Laundry service available

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Choose Your Room

Our listed hotels offer a variety of room types—double rooms, family suites, or deluxe options—all with features like breakfast, flexible cancellation policies, and exclusive deals.

Room Balcony

Max:

2 persons

315 sq. feet

Bed options:

1 King-size bed

Shower

Heating

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Deluxe King Room

Max:

2 persons

335 sq. feet

Bed options:

1 King-size bed

Shower

Heating

room details

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Deluxe King Suite

Max:

2 persons

500 sq. feet

Bed options:

1 King-size bed

Shower

Heating

room details

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Transportation Tips

Transportation Options

City Centre

Louisville 1.2 mi

Airports

Louisville (SDF) 7.4 mi

Amenities

Thoughtful hotel amenities for a comfortable stay

Free Wi-Fi

Parking

Valet parking

Luggage storage

Locker room

24-hour services

24-hour reception

General

No smoking on site
Free Wi-Fi
Parking
Safe deposit box
24-hour reception
Pets allowed
Rooms/ Facilities for disabled
Wheelchair access
Security
Luggage storage
Locker room
Allergy-free rooms
Lift
ATM/Cash machine
Smoke detectors
Electric vehicle charging station
Fire extinguishers

Sports & Fitness

Fitness centre
Yoga class

Services

Valet parking
Room service
Housekeeping
Laundry
Dry cleaning
Welcome drink

Dining

Restaurant
Bar/ Lounge area

Business

Business centre
Meeting/ Banquet facilities
Fax/Photocopying

Spa & Leisure

Spa & wellness centre
Sauna
Turkish bath
Steam room
Full body massage

Room features

Air conditioning
Heating
Mini-bar
Soundproofed rooms
Patio
Tea and coffee facilities
Ironing facilities

Bathroom

Free toiletries

Hotel Location

700 W Main Street, Louisville, Kentucky, United States, 40202

Map view

700 W Main Street, Louisville, Kentucky, United States, 40202

City landmarks

Square

Fourth Street Live

2700 ft

Stadium

Louisville Slugger Field

1.0 mi

Event hall

Kentucky International Convention Center

3000 ft

Landmark

KFC Yum Center

2300 ft

Park

Waterfront Park

4400 ft

Church

Cathedral of the Assumption

2100 ft

Landmark

Freedom Hall

3700 ft

Museum

Thomas Edison House

1.3 mi

Landmark

Angel's Envy Distillery

5200 ft

Landmark

Jim Beam Urban Stillhouse

2900 ft

Bridge

Big Four Bridge

1.4 mi

Library

Louisville Free Public Library

4800 ft

Bridge

The Big Four Bridge

1.4 mi

Landmark

Old Forester Distilling

4000 ft

Landmark

West Main Historic District

1.4 mi

Museum

African American Heritage House Museum

1.3 mi

Park

Falls of the Ohio State Park

2.5 mi

Nearby

Museum

Louisville Slugger Museum & Bat Factory

600 ft

Museum

Muhammad Ali Center

1000 ft

Museum

Kentucky Science Center

500 ft

Museum

The Frazier History Museum

900 ft

Museum

Kentucky Museum of Art and Craft

300 ft

528 W Main St

Evan Williams Bourbon Experience

700 ft

Gallery

Flame Run Glass Studio and Gallery

1000 ft

500 W Main St

The Belvedere

900 ft

Night club

Jimmy Can't Dance

300 ft

801 W Main St

Michter's Fort Nelson Distillery

500 ft

Library

Sons of the American Revolution Genealogical Research Library

700 ft

120 N 10th St

Kentucky Peerless Distilling Co

1600 ft

401 W River Rd

Belle of Louisville Riverboats

2000 ft

Restaurants

Proof On Main

100 ft

702 West Main Street

Mussel & Burger Bar Downtown

200 ft

113 S 7th St Located in Louisville's Central Business District

Bristol Bar & Grille

400 ft

614 W Main St

Atlantic No. 5

600 ft

605 W Main St Located in Louisville's Central Business District.

Los Aztecas Mexican Restaurant

600 ft

445 E Market St

Vincenzo's Italian Restaurant

1500 ft

150 S 5th St

Jockey Silks Bourbon Bar

1600 ft

140 N 4th St 2nd Floor - West Tower

Dish on Market

1600 ft

434 W Market St

Quiznos

1800 ft

223 S 5th St

Swizzle Dinner & Drinks

1800 ft

140 N Fourth St 25th Floor

Cafe Magnolia

2000 ft

140 N 4th St Galt House Hotel

Guest Reviews & Ratings

What Guests Are Saying?

4.5/5 based on 1899 reviews

#8 of 120 hotels in Louisville based on Tripadvisor

James

United States, March 2024

7.6/10

My stay at the hotel was mostly positive, with clean and spacious rooms, friendly and helpful service, and a wonderful location near downtown Louisville. However, the room's bathroom could use some improvements, and the noise level in the area affected my sleep quality.

Rooms

7.0

The room I stayed in was large, spacious, and comfortable, but I felt that the bathroom was subpar in terms of quality. Additionally, the toilet paper provided was not of the best quality.

Service

9.0

The hotel service was super helpful and friendly. The staff even gave treats to my dog, which was a lovely touch. Overall, the service was delightful.

Location

8.0

The hotel's location was fantastic for exploring downtown Louisville and visiting attractions. However, the noise in the area could be disruptive, affecting the overall experience.

Dining

7.0

I wish I had the chance to try the brunch or lunch menu during my stay, but the food I did have was very good. However, I heard that the dining experiences might not be consistent.

Facilities

7.0

The hotel facilities were satisfactory.

Christina

United States, January 2024

8.6/10

The hotel was right in the heart of downtown Louisville KY, making it perfect for exploring all the city has to offer, with spacious and quiet rooms facing the atrium. The service was exceptional, with friendly and informative staff. The dining options were good, though a bit overpriced. The location was ideal for visiting major museums and enjoying the Urban Bourbon Trail.

Rooms

9.0

The 'Butt Room' was very spacious and quiet, facing the atrium for a peaceful night's sleep.

Service

9.0

The service was delightful, with personnel always friendly and helpful, though I was puzzled by the 4-foot red plastic penguin on the 2nd floor.

Location

10.0

The hotel's location was terrific, offering easy access to great restaurants and bars, as well as being central to all that Louisville has to offer.

Dining

7.0

The dining room provided very good food, though I wish there had been more affordable options as some items felt overpriced.

Facilities

8.0

The facilities were modern and convenient, adding to the overall pleasant stay.

Thomas

United States, September 2023

7.8/10

The hotel rooms were splendidly clean, well-appointed, and very comfortable, although the lack of power sockets near the bed was slightly inconvenient. The view of the statue outside, nicknamed 'The Butt Room,' added a quirky touch to the experience. The service was prompt and accommodating, offering great suggestions for nearby activities and dining options. The central location made it convenient for exploring all that Louisville has to offer, and the proximity to major attractions was a definite advantage. The dining experience was a bit of a letdown, but the overall value for money was reasonable.

Rooms

8.0

The room was super clean, well designed, and very comfortable with lovely bed, linens, and bath products.

Service

9.0

The service was attentive and anticipatory, promptly addressing any issues and providing helpful suggestions.

Location

9.0

The hotel's central location made it convenient to explore Louisville, with easy access to major attractions and activities.

Dining

5.0

The dining experience was disappointing, and I would not recommend it. The options were limited.