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Rooms and Guests2 Guests, 1 Room
Key details

Hotel Overview

700 West Main Street, Louisville, Kentucky, United States, 40202

21C Museum Hotel Louisville - Boutique hotel with contemporary art exhibits near Muhammad Ali Center

Located in downtown Louisville, this hotel combines a contemporary art museum with a 91-room boutique hotel. Guests have access to over 9,000 square feet of exhibition space featuring curated global artworks. The property is within a half mile of the Kentucky Museum of Art & Craft, Frazier International History Museum, and Muhammad Ali Center. Dining options include Proof on Main, serving southern and Appalachian-inspired cuisine with a bourbon bar. The free electric ZeroBus stops two roads away, providing access to downtown attractions like Whiskey Row and Slugger Field. The hotel offers a 24-hour fitness center, sauna, steam room, and pet-friendly rooms.

Additional perks of the hotel

Free access to rotating contemporary art exhibitions

Onsite Reflexology treatments focusing on reflex points in feet, hands, and ears

Event spaces for 10-60 guests with tailored catering by Proof on Main

River City Tintype offers historic photography experiences

Eco-conscious meeting planning available

Private bourbon barrel program at Proof on Main lounge

Rooms & Suites

Guest rooms feature original artwork and premium Bryte Restorative Sleep Beds with adjustable temperature and firmness. The Atrium Suite includes a king bed, living/dining area, tub, and walk-in shower. Corner Suites offer four windows with views of 7th Street, Main Street, and the Ohio River. The Asleep in the Cyclone suite is an artist-designed installation with a king platform bed, record player, and curated components. All accommodations include 50-55" HDTVs, Lavazza coffee, and Malin+Goetz bath amenities.

Other conveniences

Ironing facilities and trouser press in rooms

Mini-bar and tea/coffee maker

Soundproofed rooms with carpeted floors

Private bathrooms with free toiletries and bathrobes

Some rooms feature city views

Laundry service available

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Choose Your Room

Our listed hotels offer a variety of room types—double rooms, family suites, or deluxe options—all with features like breakfast, flexible cancellation policies, and exclusive deals.
Room Balcony
2 persons
29 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
31 m² 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
61 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
46 m² 
1 King-size bed
Shower
Coffee machine
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Transportation Tips

Transportation Options

City Centre
Louisville 1.9 km
Airports
Louisville (SDF) 11.9 km

Amenities

Thoughtful hotel amenities for a comfortable stay

General

  • No smoking on site
  • Free Wi-Fi
  • Car park
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
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Hotel Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
180 m
Museum
Muhammad Ali Center
280 m
Museum
Kentucky Science Center
140 m
Museum
The Frazier History Museum
260 m
Museum
Kentucky Museum of Art and Craft
70 m
528 W Main St
Evan Williams Bourbon Experience
200 m
Gallery
Flame Run Glass Studio and Gallery
300 m
500 W Main St
The Belvedere
250 m
Night club
Jimmy Can't Dance
90 m
801 W Main St
Michter's Fort Nelson Distillery
150 m
Library
Sons of the American Revolution Genealogical Research Library
190 m
120 N 10th St
Kentucky Peerless Distilling Co
480 m
401 W River Rd
Belle of Louisville Riverboats
580 m
Restaurants
Proof On Main
10 m
702 West Main Street
Mussel & Burger Bar Downtown
60 m
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
110 m
614 W Main St
Atlantic No. 5
160 m
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
180 m
445 E Market St
Vincenzo's Italian Restaurant
430 m
150 S 5th St
Jockey Silks Bourbon Bar
480 m
140 N 4th St 2nd Floor - West Tower
Dish on Market
470 m
434 W Market St
Quiznos
540 m
223 S 5th St
Swizzle Dinner & Drinks
530 m
140 N Fourth St 25th Floor
Cafe Magnolia
590 m
140 N 4th St Galt House Hotel
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Check-in
20Nov2025Select date
Check-out
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Rooms and Guests2 Guests, 1 Room